Research, development, registration, manufacturing and distribution of biologically active materials
Natural active ingredients also in the most effective way of treatment - the prevention
Plant drugs have significance in modern phytotherapy too
Factors causing hyperaemia in the mucous membrane of the bladder play a role in the development of its inflammation. This can happen after cold, due to inflammation of surrounding organs, maybe after eating certain (spicy) foods. Hyperaemia and the urine-stagnation due to incomplete voiding favour bacteria settling in the bladder. Both acute and chronic cystitis is caused most frequently by E.coli.
Women are more susceptible to cystitis due to their anatomy (shorter urethra). The most common causes of cystitis are sexual intercurse. The marked stinging and burning pain, constant urge to urinate and dysuria which accompanies cystitis is familiar to two-thirds of women.
In men, similar situations can occur mainly because difficulties with uresis. This may result from bladder outflow obstruction (prostatic hypertrophy).
Cystitis can be very painful and distressing. If the acute cystitis will not be treated adequately in time, it would become chronic.
Besides antibiotic treatment, medicinal herbal products have a significant role, as adjuvants, in promoting recovery.
Urogin tincture is a natural product, prepared from six medically useful herbal extracts. The natural plant (bearberry leaf, yarrow, agrimony, stinging nettle leaf, birch leaf and field horsetail) constituents of the tincture - alone or in different combinations or in combined preparations and tea-mixtures - have been used in folk medicine for a long time.
These natural remedies are effective in case of uncomplicated infections of the lower urinary tract, such as cystitis, when antibiotic treatment is not considered essential. Application of plant drugs have significance in modern phytotherapy too.
Uvae ursi folium (Bearberry leaf): The main constituent of bearberry leaf is arbutin (5-15%), a phenolic glycoside that becomes hydrolyzed to hydroquinone. Both chemicals contribute to the antiseptic effects in the urinary tract. Arbutin alone has been reported to relieve pain from kidney stones, cystitis (bladder infection) and nephritis (kidney inflammation). This herb - due to its antibacterial and antiinflammatory properties is approved in Germany for treatment of bladder infections.
Achilleae herba (Yarrow): The drug yarrow contains 0,1-1% essential oil, out of which the quantity of azulene (chamazulene) can reach 40%. The antiinflammatory pharmacology is due to this compound.
Yarrow has been used for thousands of years (from Trojan War) as a healer of wounds helping to control hemorrhages and infections. Its primary historical efficacy is as a hemostat, antimicrobial, antiinflammatory, cell proliferator and mild analgesic. The herb also acts as a system purifier that rids the body of toxins through the skin and urinary tract. Yarrow is active against E. coli and many other bacteria. The flavonoids (apigenin) play an important role in the antispasmodic activity of this plant. Apigenin was found to induce astringency perception.
Agrimoniae herba (Agrimony): Agrimony was one of the most famous vulnerary herbs with antiinflammatory and diuretic properties. The tannin content (4-10%) is responsible for many of its medicinal uses. Agrimony may be useful against certain bacterial and viral infections, against inflammations of mucous membrane in the kidney and bladder.
Urticae folium (Stinging Nettle leaf): Nettle leaf is a great source of vitamin C and K. Its constituents include beta-sitosterol and flavonoids quercetin, rutin, kaempferol. In addition to antiinflammatory effects, the leaf also demonstrates analgesic, hemostatic, antibacterial, and antiviral activities.
The plant and leaf of stinging nettle have been used for kidney and bladder stones, rheumatism, urinary tract infections and pain.
The extract has been shown to reduce the proinflammatory cytokines. It is suitable for irrigation in inflammatory conditions of lower urinary tract.
Betulae herba (Birch leaf): It contains 2-3 % flavonol glucoside, principally hyperoside and quercitrin. Extract of birch leaves has antiinflammation, disinfectant, diuretic properties. Internally, it can be used for cleaning urinary tract (it increases diuresis), especially in case of inflammations and kidney stone, as well as for adjuvant treatment of bacterial infections of the urinary tract.
Equiseti herba (Field Horsetail): Horsetail herb contains considerable amount (5-8%) of silicates (10% of which is water-soluble), alkaloids, flavonoids and tannic substances.
The plant drug improves urination, has styptic and antiinflammatory effects, helps to remove lead compounds from an organism. Most living organism tissues contain silicic acid and its salts, which influences the formation of collagen. Horsetail preparations are used as a diuretic and styptic remedy in case of inflammatory kidneys and urinary system diseases, gravel and salt metabolism disorders. Also used in the treatment of incontinence and bedwetting in children, because of its toning and astringent actions.
Birch, horsetail, and nettle are approved in Germany as part of the therapy of people with urinary tract infections. These herbs appear to work by increasing urinary volume and supposedly helping to flush bacteria out of the urinary tract.