Research, development, registration, manufacturing and distribution of biologically active materials
Natural active ingredients also in the most effective way of treatment - the prevention
Fungal infections of the skin
There are three genera of moulds that contain the Dermatophytosis-causing species. These are: Epidermophyton, Trichophyton and Microsporum. They have strong association with fungal infections of the skin, hair, and nails.
Tinea is the medical name for a group of related skin infections, including athlete s foot, jock itch, and ringworm. They are caused by several types of mould-like fungi (dermatophytes) that live on the superficial dead tissues of the skin, scalp (hair), and nails and thrive in warm, moist areas like the insides of the thighs.
It can be difficult to avoid ringworm because the dermatophyte fungi are very common. Their most common sources that cause tinea infections are other people. To protect yourself against infection, it can help to wear flip-flops on your feet in the locker room shower or at the pool, and to wash sports clothing regularly. Patients with an impaired immune system are at risk from fungal infections.
Ringworm of the skin starts as a red, scaly patch or bump which tends to be very itchy and uncomfortable. When ringworm affects the feet it is known as athlete s foot, characteristically growing between the toes. It is highly contagious and, if left untreated, can spread to the bottom of the foot and the toenails. Ringworm of the nails may affect one or more nails on hands or feet of a person. The nails may become thick, white or yellowish, and brittle.
Jock itch is a common fungal infection of the groin and upper thighs. When the groin area gets sweaty and is not dried properly, it provides a perfect environment for the fungi to multiply and thrive.
Ringworm of the scalp (dandruff), may start as a small sore that resembles a pimple before becoming patchy, flaky, or scaly. It may cause some hair to fall out. It can also cause the place where the infection is to become swollen, tender, and red.
Candida albicans, a yeast, causes thrush infections and vaginal yeast infections, and is part of the diverse fungi family.
Good general hygiene is vital to prevent fungal infections. Fungi often infect the skin surface and subsequently invade the cornea.
Pharmacologic agents applied to the surface of the skin readily penetrate into the cornea to kill the fungi (fungicidal agents), or at least render them unable to grow or divide (fungistatic agents). Yeast infections such as those caused by Candida albicans respond well to azole drugs.
Even with successful treatment, it is common for the fungus to return.
Nail infections are difficult to cure with topical therapies because the infections usually occur under the nail and products penetrate poorly. Even with successful treatment, it is common for the fungus to return. Infections of hair follicles, nails often require systemic treatments.
Topical therapies work well to rid the skin of topical fungi and yeasts. Athlete s foot can be treated locally with antifungal creams, ointments, sprays, lotions or powders that are available from pharmacists without a prescription.
Combined treatment consisting of an antifungal cream and a corticosteroid reduces inflammation and irritation in case of tinea pedis with secondary bacterial infection.
Gombarex lotion for external use is a natural product with medically proven effectivity against superficial fungal infection like tinea pedis.
It is a herbal combination of the aqueous-ethanolic extracts from: english walnut leaf, hyssop, garden thyme, oak bark, ribwort plantain leaf and silverweed cinquefoil.
Pharmacological effects of the plant constituents and their indications
The walnut tree has a long history of medicinal use. Its leaves are detoxifier, anthelmintic, antiinflammatory and astringent. They are used internally for the treatment of constipation, chronic coughs, asthma, diarrhoea, dyspepsia, etc. The leaves are also used to treat skin ailments and purify the blood. Their main ingredients are: approximately 10% tannins of the ellagitannins type; small amount of essential oil; naphthalene derivatives especially the monoglucosides of juglone and over 3% flavonoids.
English walnut leaf - as an antifungal was used in the past for candida yeast infection, ringworm, athlete s foot, and thrush. This effect as well as anthelmintic, anticancer and antibacterial properties are due to ellagitannins and juglone and its essential oils.
Hyssop is a member of the mint family with a camphor-like odor due to its aromatic oils. Constituents are: volatile oil, flavonoid, diosmin, tannin. The hyssop has been popular since the biblical days for its soothing and detoxifying effect. It helps effectively to relieve stress and anxiety while boosting mental activity.
Hippocrates recommended the use of hyssop for bronchitis and other inflammations of the chest and lungs. For centuries it was used as a medicinal herb against coughs and catarrh. The oil was part of an old english country remedy for cuts, wounds and bruises. Infusion of the leaves has been applied topically to cure pain caused by rheumatism.
The hyssop essential oil has stimulant and antiseptic affects, it should therefore only be taken with care and in much diluted form. Hyssop is antiperspirant and astringent (can be used in deodorants), contains substances which protect the skin against sunburn.
Ancient egyptians used thyme for embalming, greeks burnt it as incense in their temples. In the european middle ages, the herb was placed beneath pillows to aid sleep and ward off nightmares.
The medicinal action of thyme is attributed to its volatile oil constituents, thymol (an antiseptic) and carvacrol. Thyme is used primarilly for respiratory infections. Before the advent of modern antibiotics, it was used to medicate bandages. The garden thyme essential oil possesses a wide range spectrum of fungicidal activity - it is effective against the fungus that commonly infects toenails. It can be considered as a potential antimicrobial agent. It has antiinflammatory and antiodorant properties.
Oak bark, an astringent, has also antiphlogistic and antiperspiration effects, it improves wound healing and re- epithelization.
Its extract has been used for years as a topical medication for the inflammation and irritation associated with many common forms of dermatitis, including conditions like pyodermas, insect bites, burns, and fungal infections. There is a decoction of oak bark or walnut leaves to treat ringworm and athlete s foot. Decoction of oak bark was used by native american cultures for hundreds of years to treat wounds (american military is still using it). Oak bark is rich in tannins and provides vitamin B12 and minerals like zinc, iron and calcium. The tannins are believed to draw out irritants, toxins and inflammation in the skin.
Ancient greek and romain medicine valued and gave credit (as did indians and maoris) to the healing power of the ribwort plantain.
The drug is anti-hemorrhagic, astringent, hemostatic and soothing. Plantain is popular as a healer of wounds and injuries as well as a remedy for most poisons. It is also effective in treating fevers, infections and skin diseases. The herb is able to cure hemorrhoids and excessive menstrual bleeding. It helps stop dandruff.
Plantain contains a high percentage of mucilage, which gives its soothing properties; allantoin, to speed wound healing; flavonoids (including apigenin), against inflammation and aucubin (an irridoid glycoside), - the most important constituent of the leaves - a strong antimicrobial substance to help prevent infections. The astringent property of the leaves due to the tannin makes the leaves useful for all types of sores on the skin, cuts, bites and various inflammations.
The genus name Potentilla (silverweed, sometimes called goosewort) was given to these plants based on the powerful (potent) healing effects attributed to the herbal medicines derived from it. The whole plant has therapeutic effects: it cools, fortifies, and acts as an astringent.
In chinese medicine, potentilla is a commonly used remedy for diarrhea. Its rootstock has been consumed as food by the native americans, chinese, and europeans for centuries.
Major components of interest in potentilla species are tannins in form of ellagitannins, similar to those found in green tea. The herb also contains antioxidant flavonoids (glycosides) and proanthocyanidins. In the leaves of Potentilla anserina also accumulate polyphenols which appear to have antiviral activity. Also, its high tannin content makes it a useful treatment for sore throat, oral and skin ulcerations (wound), bleeding, and diarrhea. The tannins also have antibacterial action.